CATH – a hierarchic classification of protein domain structures
نویسندگان
چکیده
منابع مشابه
CATH--a hierarchic classification of protein domain structures.
BACKGROUND Protein evolution gives rise to families of structurally related proteins, within which sequence identities can be extremely low. As a result, structure-based classifications can be effective at identifying unanticipated relationships in known structures and in optimal cases function can also be assigned. The ever increasing number of known protein structures is too large to classify...
متن کاملClassifying a protein in the CATH database of domain structures.
The CATH database of protein domain structures classifies structures according to their (C)lass, (A)rchitecture, (T)opology or fold and (H)omologous family (http://www.biochem.ucl.ac.uk/bsm/cath). Although the protocol used is mostly automatic, manual inspection is used to check assignments at some critical stages, such as the detection of very distantly related homologues and anologues and the...
متن کاملSequence analysis Functional classification of CATH superfamilies: a domain-based approach for protein function annotation
Motivation: Computational approaches that can predict protein functions are essential to bridge the widening function annotation gap especially since <1.0% of all proteins in UniProtKB have been experimentally characterized. We present a domain-based method for protein function classification and prediction of functional sites that exploits functional sub-classification of CATH superfamilies. T...
متن کاملFunctional classification of CATH superfamilies: a domain-based approach for protein function annotation
MOTIVATION Computational approaches that can predict protein functions are essential to bridge the widening function annotation gap especially since <1.0% of all proteins in UniProtKB have been experimentally characterized. We present a domain-based method for protein function classification and prediction of functional sites that exploits functional sub-classification of CATH superfamilies. Th...
متن کاملThe history of the CATH structural classification of protein domains
This article presents a historical review of the protein structure classification database CATH. Together with the SCOP database, CATH remains comprehensive and reasonably up-to-date with the now more than 100,000 protein structures in the PDB. We review the expansion of the CATH and SCOP resources to capture predicted domain structures in the genome sequence data and to provide information on ...
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ژورنال
عنوان ژورنال: Structure
سال: 1997
ISSN: 0969-2126
DOI: 10.1016/s0969-2126(97)00260-8